Scientist Shin Kubota expresses his vision in the New York Times: « Turritopsis application for human beings is the most wonderful dream of mankind,” he told me the first time I called him. “Once we determine how the jellyfish rejuvenates itself, we should achieve very great things. My opinion is that we will evolve and become immortal ourselves.”. » (November 28, 2012)

Theme of the month : Longevity records of living organisms

How to understand the longest lifespan? And why? 

The maximum lifespan of living things is extremely variable depending on the species. Overall, for animals, the maximum lifespan is longer with one or more of the following favorable factors:

• Predators are rare 
• The metabolism is slow 
• Size is large

The differences in lifespan can be enormous between species that are biologically quite close. This is one of the reasons to consider gene therapy or other medical treatment to dramatically increase the maximum lifespan of humans.

This letter includes known cases of extreme longevity. Obviously, in these cases of very long lifespans, only indirect and sometimes questionable measures are possible.

The naked mole rat and the bat, exceptional longevity and no cancer! (35-40 years)

The longevity of naked mole rats is especially surprising when compared to other captive rodents of similar size. Naked mole rats are not expected to live more than six years. However, the oldest naked mole rat known in the laboratory is… 35 years old! And, among some of its fellow rats that are over 30 years old, some females are still fertile.

Researchers have discovered why naked mole rats are cancer-free. It is thanks to hyaluronic acid, a molecule that is thought to prevent the formation of tumors in the body. According to researchers Vera Gorbunova and Andrei Seluanov, who published their results in the journal Nature, the molecular weight of hyaluronic acid in the naked mole rat is five times greater than in mice.

The tiny Brand’s bat, at seven grams, lives for almost forty years. It is the same for the great mouse (Myotis myotis), which is five times heavier. An international team undertook a longitudinal study over eight years. Their results, published in the journal Nature Ecology & Evolution, open up promising avenues for research on aging.

Longest-lived insect: the termite queen (50 years)

Insects are normally thought of as living less than a year as adults. However, termite queens, protected from predators, can reach 50 years.

Birds: The albatross can live up to 80 years

Albatrosses are the largest seabirds in the world: the howler albatross reaches a wingspan of 3.50 meters! Their longevity is also remarkable, as they can live up to 80 years. Wisdom, a 70 years old albatross has laid eggs again. A parrot (cockatoo) has also reached a similar age (82 years).

Oldest amphibian: the cave salamander (100 years)

Naturalists attribute the longevity of the blind salamander Proteus anguinus to its unusually slow metabolism. Tthis salamander takes 15 years to mature, mates and lays eggs only about every 12 years, and barely moves except when foraging for food. In addition, the damp caves of southern Europe where it lives are virtually free of predators, allowing P. anguinus to live beyond 100 years in the wild.

Reptiles: The famous Galapagos tortoises

In 2012, « Lonesome George » died at over 100 years old. Six years after his passing, the centenarian has made a comeback thanks to the revelations of Yale researchers studying his genome! George was the last representative of a species endemic to a Galapagos island. He always shunned any mating in captivity. The scientists who had sequenced his genome during his lifetime as well as that of another species of giant tortoise, revealed the results in the journal Nature.

The biologists detailed 891 genes in these turtles, involved in the function of the immune system. They show that these animals have developed extra copies of genes that allow them to better respond to oxidative stress, known to be a major factor in aging. They also discovered a gene that allows cells to better defend themselves against foreign cells, as well as tumor suppressor genes that are more numerous than in most vertebrates, and others that are involved in DNA repair.

The study of aging in animals is a source of knowledge for humans. Researchers have found some similarities between the genomes of turtles and centenarians.

Jeanne Calment with her 122 years is the person who lived the longest in the history of humanity…, but certainly not enough to impress an old turtle. The longest living turtle seems to have reached 189 years of age.

Sphenodons are other reptiles that can live past a century.

Fish: 150 years for the orange roughy (Hoplostethus atlanticus)

Hoplostethus atlanticus is called « watchfish ». The animal lives in the world’s oceans at depths between 900 and 1,800 meters, especially in submarine canyons.

The species only reaches sexual maturity between 20 and 30 years of age, which could be explained by a low predation rate and the scarcity of prey in the abysses. Adults can measure 75 cm long and weigh 7 kg and the age of the oldest known specimen, determined by radiometric radiation of the mineral accumulations in its internal ears, is said to  be 149 years.

Echinoderms: 200 years for the giant red sea urchin (Astropyga radiata)

Quite common in the Indian Ocean and in part of the Pacific Ocean, this echinoderm owes its name to its color and its size, which can reach nearly 20 cm in diameter, the largest known among sea urchin species. Some individuals have reached the age of 200 years.

Mammals: 200 years for the bowhead whale (Balaena mysticetus)

Living in Arctic waters, the bowhead whale is a cetacean measuring up to 20 meters and weighing around 100 tons. Its longevity has been estimated at more than 200 years thanks to scars left by old wounds caused by whale hunters. This exceptional longevity could be explained by certain genes. For example, analysis of the whale genome shows unique mutations in the ERCC1 gene involved in the repair of damaged DNA. Another gene, called PCNA and associated with cell growth and DNA repair, contains a duplicate section of DNA. This duplication could slow down cetacean aging.

Sharks: 400 years for the Greenland shark (Somniosus microcephalus)

This rather plump grey shark, measuring five meters, lives in the waters of the Arctic Ocean and is the champion of longevity among vertebrates. Its growth is estimated at about 1 cm per year.

In an article published in Science, an international team of researchers describes how they managed to measure the age of 28 Greenland sharks. The results revealed that the largest shark, a female over five meters long, was 392 years old, although there is a significant margin of error of plus or minus 120 years. The sexual maturity of females is thought to be reached at the age of about 150 years.

According to this research by Julius Nielsen at the University of Copenhagen, published in August 2016, the Greenland shark would therefore be the longest-living vertebrate.

Oldest Mollusc: The Ocean Quahog (500 years)

Scientists have determined that the ocean quahog, Arctica islandica , can literally survive for centuries, as demonstrated by one individual, Ming, which has surpassed the 500-year mark (you can determine a mollusk’s age by counting the growth rings in its shell).

Trees. The Giant Sequoia: over 3000 years old!

Some trees seem to have no senescence mechanism. They remain as fertile at the age of several centuries as in their youth.

The Giant Sequoia is characterized by its longevity since it can reach more than 3000 years. 

Many other species of trees can live for centuries: olive trees, oaks. The absolute record seems to be held by a 5,000 year old Bristlecone pine.

Finally, trees, like other plants, can multiply clonally and form a collective organism. In this sense, the clonal colony of aspen Pando is, at 80,000 years, one of the oldest organisms on the planet.

Microscopic organisms: endoliths (10,000 years)

Determining the lifespan of a microscopic organism is a tricky question: in a sense, all bacteria are immortal, as they propagate their genetic information by constantly dividing (rather than having sex and dying of age).

The term « endoliths » refers to bacteria, fungi, amoebas, or algae that live deep underground in cracks in rocks. 

Studies have shown that individuals in some of these colonies undergo cell division only once every hundred years and can have a lifespan of about 10,000 years. 

Technically, this differs from the ability of some microorganisms to recover from stasis or freezing after tens of thousands of years; in a significant sense. Endoliths are continuously « alive », though not very active. Perhaps most importantly, endoliths are autotrophic, meaning that they fuel their metabolism not with oxygen or sunlight, but with inorganic chemicals, which are virtually inexhaustible in their underground habitats.

Biological immortality in lobsters, hydras, sponges and corals

A small number of multicellular animals seem to have no mechanism of senescence. They do not degrade as they age. For example, their fertility remains constant or even increases.

Hydras, like all cnidarians, can regenerate, which allows them to recover from an injury and reproduce asexually. All hydra cells divide continuously. It has been suggested that hydras do not undergo senescence and, as such, are biologically immortal. In a four-year study, three cohorts of hydras showed no increase in mortality with age.

One species of sponge can live up to 11,000 years, namely Monorhaphis chuni, according to a U.S. study published in the journal Aging Research Reviews in 2014.

Some colonial animals, such as corals, can live more than 4,000 years.

Research suggests that lobsters may not slow down, weaken or lose fertility with age, and that older lobsters may be more fertile than younger lobsters. This does not, however, make them immortal in the sense of no impact of senescence, as they are much more likely to die in a shell molt with advancing age due to their increasing size. 

Their longevity may be due to telomerase, an enzyme that repairs long repetitive sections of DNA sequences at the ends of chromosomes, called telomeres. Unlike vertebrates, lobsters express telomerase in adulthood throughout most tissues, which has been suggested to be related to their longevity.

It has been claimed that some fish, notably the bigmouth buffalo, do not have measurable senescence. However, with the exception of the Greenland shark, no captured fish whose age was measured exceeded 200 years.

Why no biological immortality in vertebrates, even those without predators?

Natural selection, at least for vertebrates, always results in species with limited lifespans. This can be explained by the fact that an animal species without aging would lose its genetic diversity and be eliminated by any environmental change. This also explains sexual reproduction: more genetic mixing means more adaptability to the environment. 

But in a certain sense, systematic aging remains an evolutionary mystery. Indeed, even salamanders or cave fish in an extremely stable environment (hundreds of thousands of years) and without predators do not seem to live much beyond a century.

Cnidaria: biological immortality and rejuvenation for the jellyfish Turritopsis nutricula

Small in size, but long in life expectancy. The jellyfish Turritopsis nutricula measures only 5 mm in diameter, but could live ad vitam æternam. Native to the Caribbean Sea, the species is nowadays very widespread. Several specialists are worried about its proliferation over the whole globe.

Thanks to a particular cellular process called transdifferentiation, the animal is able to stop its aging and even to become younger. It is already known that the best way to push a Turritopsis Nutricula to regenerate is to stress it. For example, in case of an injury, the process starts immediately and within a few days, the jellyfish returns to its juvenile stage and starts a new life.

This makes it an exceptional subject of study for biologists and geneticists, and a subject of interest for some pharmaceutical groups who are already considering the production of a rejuvenating cream containing Turritopsis DNA. « It’s as if a butterfly were able to go back to the caterpillar stage, » says Stefano Piraino, a professor at the University of Salento in Italy.

Dormancy as a longevity strategy

Dormancy is a term that covers all forms of slowed life. 

It is the period in the life cycle of an organism when growth, development and/or physical activity (in animals) are temporarily stopped. This reduces metabolic activity and thus helps the organism to conserve energy.

Especially in extreme environments, or ones of a very seasonal nature, dormancy can only be an adaptive strategy if a stimulus for the seed to move from a « dormant » to a « non-dormant » state is made possible at the « right time ». And indeed, dormancy often does indeed cease when environmental conditions permit.

The longevity of a seed (the length of time it can remain in a dormant state without losing its ability to germinate) is highly variable. In plants, all the intermediaries exist, between the seed of the lotus which holds the record of longevity (about1000 years) and the seeds of cocoa tree, little dehydrated, which must, under pain of death, find, in the few days following their maturation, conditions allowing their germination. Scientists have even managed to germinate seeds of silence (a plant with white flowers) frozen for nearly 32,000 years in the Siberian subsoil! 

Although costly, the dormancy strategy prevents all individuals carrying the same genotype from simultaneously encountering an environment not conducive to their survival or reproduction.

A rotifer survived 24,000 years of freezing in the Arctic permafrost.

Bdelloid rotifers generally live in aquatic environments and have an incredible ability to survive. Russian scientists discovered these creatures in a core of frozen soil extracted from the Siberian permafrost using a drill.

In a study published recently in the journal Current Biology, the Russian researchers used radiocarbon dating to determine that the creatures they recovered from the permafrost (ground that is frozen year-round, except for a thin layer near the surface) were about 24,000 years old.

This is not the first time ancient life has been « revived » from a permanently frozen habitat.

Antarctic moss stems were successfully regenerated from a 1,000-year-old sample and a living campion flower was regenerated from seed tissue, probably stored by an Arctic squirrel, that had been preserved in 32,000-year-old permafrost. Simple worms, called nematodes, were « resurrected » from permafrost at two locations in northeastern Siberia in sediments more than 30,000 years old.

This month’s good news: Private investments for longevity. The European Union announces widespread health data sharing for its citizens by 2025.

• Vitalik Buterin donates over $2 million to the Methuselah Foundation.
• Michael Greve, founder of Forever Healthy, pledges 300 million to advance rejuvenation startups.
• In an unfortunately poorly circulated document, the European Commission announces that it aims to have EU citizens able to share their health data with the healthcare providers and authorities of their choice by 2025. This would mean, if followed through, that European citizens will be able to easily share their data for scientific research, including healthy longevity.

For more information:

• See in particular: heales.org, sens.org, longevityalliance.org and longecity.org.
• Source of image

Thomas Pesquet, the current star of French scientific research: « If we could unlock the key to aging and figure out how to reverse it, that would be super convenient. » (translation)

Theme of the month: Regeneration

All living beings are capable, at different levels, of repairing damage to their organism. 

In biology, regeneration is the capacity of living organisms to rebuild themselves after a natural or accidental destruction of a part of themselves. 

Stem cells: the key to regeneration?

Regeneration can involve cells, organs or functional parts of certain living beings. The ability to regenerate is mainly carried by cells of the body that will reprogram themselves to replace the damaged tissue or organ. Some of these cells called « stem cells » are generated either by the bone marrow and can circulate in the body, or by the tissues themselves.

 Regeneration in humans

The human body is constantly subject to cell death and regeneration. However, this regeneration is not exactly the same depending on the type of organs and cells.

Some cells are completely replaced by new ones in a very short time. For example, the cells of the intestines and stomach are only used for a few days before being evacuated by the body. The skin is completely renewed in a few weeks due to external aggressions. Some cells even live only a few hours, like white blood cells.

On the other hand, some cells are renewed slowly. For example, it takes about ten years for bones to be completely regenerated. Heart muscles regenerate by only 1% each year after the age of 20.

But our body also contains cells that never regenerate! This is the case of oocytes or certain neurons in the cerebral cortex.

We must not confuse regeneration and healing, even if they can be observed together, they are two very distinct phenomena. Healing is only a partial repair of the cells, but does not allow an identical reproduction.

We certainly cannot regrow a leg or an arm, but some animals can regenerate whole parts of their body!

Regeneration in living beings

The regeneration capacities of certain plants, notably trees, are remarkable. But the genetic and physiological functioning is so different from that of animals, and therefore also from that of humans, that there is no prospect of application against human senescence appearing conceivable in the short or medium term.

The ascidian, a curious small marine invertebrate in the shape of a wineskin, has the ability to renew its tissues very quickly after serious injuries. Other invertebrates, such as the flatworm and the planarian, can regenerate their head from a tail fragment and vice versa. These invertebrates are not the only animals with such regenerative powers.

Among vertebrates, too, we can find experts in regeneration. The axolotl, a small amphibian that can regrow its limbs, organs and even parts of its brain. The zebrafish regenerates its heart tissue without needing stem cells. Salamanders regenerate their limbs, heart, tail, eyes, kidneys, brain and spinal cord throughout their lives. 

How do these animals with regenerative abilities manage to regrow such complex structures?

Understanding the regeneration process

After an amputation, stem cells accumulate at the site of injury in a structure called the blastema. A major part of current research focuses on how signals from the injury site indicate to stem cells to form the blastema and begin dividing to rebuild the missing structure. 

But what happens at the level of the stem cells themselves? Do the animals use a single type of blastema stem cell that can differentiate into multiple tissues? Or do different groups of stem cells produce the different tissues required to form the new organ?

Recent research in animals with regenerative abilities has shown that stem cells use a variety of strategies to reconstitute missing body parts from multiple tissues, such as muscle, nerve and skin. 

In this 2014 study, scientists combed through the 23,000 genes of Anolis carolinensis, a lizard about 20 centimeters long. Its complete genetic sequencing had already been completed in 2011. But this time, the study’s researchers scanned all the genes during tail regeneration to isolate those responsible. The result: at least 326 genes are activated in the phenomenon, a real « recipe » in the lizard’s DNA.

Another group of scientific researchers in the United States recently solved the mystery of planarian worm regeneration. They discovered that adult individuals have pluripotent stem cells that can make all types of cells in the animal’s body. 

In addition to stem cells, the regeneration process uses differentiated cells that have stopped dividing and « start » to multiply again to replace lost tissue. This phenomenon is present in zebrafish where a heart muscle cell divides to reconstitute the missing tissue. This regenerative process has also been demonstrated in the heart of young mice, but it quickly disappears as the animal grows.

Future Research and Challenges: Enabling human rejuvenation through regeneration

As adults, humans can regenerate certain organs such as the liver or skin. Unfortunately, many other human tissues do not have this ability. One of the goals of regenerative medicine is to find ways to stimulate tissue regeneration or make replacement tissues. One day, this could be one of the ways to « cure » humans of aging.

In December 2018, the scientist Michael Levin from Tufts University, demonstrated that by changing the electrical pattern between cells in the planarian worm this resulted in activation of cells indicating to the body its shape by guiding regeneration.

How to limit growth to what is useful (avoid cancerous growths)? How to « start », « reactivate » these mechanisms to allow the regeneration of organs that arenot destroyed, but senescent? This research requires a better understanding of the genetic and molecular mechanisms of regeneration. 

Progress in the use of stem cells, gene therapy, and the knowledge of genetic mechanisms linked to regeneration open up considerable perspectives. This could well be one of the avenues studied by the USA in the framework of the initiative announced below.

Good News of the Month: U.S. President Joe Biden Announces Advanced Health Care Agency in First Address to U.S. Congress

« The Department of Defense has an agency called DARPA (Defense Advanced Research Projects Agency), whose mission is to develop advances to strengthen our national security. This agency gave birth to the Internet, GPS and many other things. The National Institutes of Health, NIH, should create a similar agency for advanced research projects in the health field. To develop breakthroughs – to prevent, detect and treat diseases like Alzheimer’s, diabetes and cancer.

This is a personal issue for many of us. I can’t think of a more worthy investment. And I don’t know of anything more bipartisan. Let’s end cancer as we know it. It’s within our power. » (Source)

The DARPA agency specializes in « disruptive » technologies. So this new agency could quickly target « disruptive » research in health and anti-aging.

For more information:

• heales.org, sens.org, longevityalliance.org and longecity.org.
• Source of the image

Levelling up health is important. We want to level up life and you can only level up life by levelling up life expectancy. Matthew Hancock. 1921. British Secretary of State for Health and Social Care (source).

Theme of the month: Secrets of longevity of blue zones 

Worldwide, life expectancy is currently about 71 years. In 2019, life expectancy at birth in Belgium was 81.8 years for the total population, 84.0 years for women and 79.6 years for men.  In some Asian countries (Singapore, South Korea, Japan), it is even higher.

However, this is less than the exceptional longevity observed in specific areas of our planet where there is a large proportion of centenarians. These regions were identified by two demographers, Gianni Pes and Michel Poulain, and the journalist Dan Buettner, author of the article The secrets of Long Life published in the National Geographic magazine and the book The Blue Zones.

The 5 Blue Zones identified in the world

Sardinia, Italy

By studying the longevity of the inhabitants of Sardinia, demographers Pes and Poulain and their collaborators have located areas where more centenarians live. These longevity hotspots or Blue Zones (the researchers initially used a blue marker to delimit these zones on a map) are located in a mountainous region of the island, the Barbagia, which was still difficult to access a few decades ago. Such a geographical situation favors inbreeding, reducing the diversity of the genetic heritage. In the area of exceptional longevity, in the southeast of the province of Nuoro, 91 people became centenarians among the 18,000 people born in the area between 1880 and 1900. In one particular village (Seulo), 20 centenarians were counted between 1996 and 2016. 

Analysis of genes involved in inflammation, cancer and heart disease did not reveal any significant differences that could be related to the exceptional longevity of the Sardinians. The researchers therefore suspect that environmental characteristics, lifestyle and diet are much more important than genetic predispositions for living long and healthy lives. 

Many of these Sardinian centenarians are shepherds or farmers who have done a lot of physical activity outdoors throughout their lives. The Sardinian diet, which is part of the famous Mediterranean diet, could play an important role. It consists of home-grown vegetables (especially beans, tomatoes and eggplant), whole grain bread, pecorino cheese made from whole milk from grass-fed sheep, and local red wine particularly rich in polyphenols. The diet includes meat only once a week at most.

When centenarians are asked about their exceptional longevity, they frequently mention the importance of family and social ties. In Sardinia, the elderly live with family, not in nursing homes. Seniors living in the Sardinian Blue Zone report excellent mental well-being and few symptoms of depression. An Italian study of 160 seniors in this Sardinia Blue Zone reported that the trait of resilience was significantly associated with markers of good mental health. 

Okinawa, Japan

Japan has one of the highest concentrations of centenarians in the world, more than 34.7 per 100,000 inhabitants in 2010. Inhabitants of the Okinawa archipelago in southwestern Japan have a particularly high life expectancy and 66.7 centenarians per 100,000 inhabitants have been counted in this prefecture. Women living in Okinawa are 3 times more likely to live to 100 than North American women. The exceptional longevity in Okinawa is the result of a set of favorable factors that are not limited to genetic heritage. Most of these factors are highly cultural and related to the traditional Okinawan lifestyle.

The Okinawan diet is based on plants, many green leafy vegetables, sweet potatoes, fish and seafood. The majority of Okinawan centenarians have maintained a vegetable garden throughout their lives, moderate physical activity to keep fit and reduce stress. Okinawans traditionally practice self-restriction by following the Confucian-inspired teaching of « hara hachi bun me » which recommends eating so as to be 80% full at the end of a meal. The elderly in Okinawa are very active and maintain strong family and social ties, for example during regular meetings called « moai ». It is very important for them to give meaning to their lives, to have an « ikigai » i.e. to have a reason to get up every morning.

Nicoya, Costa Rica

Life expectancy is relatively high in Costa Rica (82.1 for women and 77.4 for men), but it is especially high in one region of the Nicoya Peninsula where men aged 60 are 7 times more likely to become centenarians than other Costa Ricans. Like Sardinia, Nicoya is a region that has been relatively isolated for hundreds of years. It has a 23% lower death rate from cancer than the rest of the country. Nicoyans eat a plant-based diet (squash, black beans, corn tortillas, lots of local fruits), but also include eggs and meat (chicken and pork). Nicoya centenarians are very physically active, have strong family ties, a strong religious faith and enjoy working. They have very little stress and are generally very positive and happy.

Loma Linda, USA

The only identified Blue Zone in North America is located in Loma Linda, a city in California where there is a community of 9,000 members of the Seventh-day Adventist Church. In California, an Adventist male aged 30 will live an average of 7.3 years longer than a white Californian of the same age. A 30-year-old Adventist woman will live an average of 4.4 years longer than a California woman of the same age. Given that about two-thirds of Americans die from cardiovascular disease and cancer, it is not surprising that Adventists live longer since their lifestyle puts them at less risk for these diseases. About half of Adventists are vegetarians or rarely eat meat and non-vegetarians are twice as likely to develop cardiovascular disease. The majority of Adventists are non-smokers and do not drink alcohol. As a result, they have a lower incidence of lung cancer than Americans in general. Adventists are physically active and have a strong sense of community, as they are very religious and their church encourages members to help each other.

Ikaria, Greece

Icaria is an island in the eastern Aegean Sea where one in three inhabitants reaches the age of 90. The incidence of cancer, cardiovascular disease, diabetes and dementia is significantly lower. As in Sardinia, Okinawa and other Blue Zones, Icarians maintain a vegetable garden at home and lead a low-stress life. The Icarian diet is Mediterranean in style and consists of vegetables (potatoes, peas, lentils, green leafy vegetables), fruit, olive oil, fish, goat’s milk, dairy products and a little meat. Icarians eat little sugar and drink coffee, red wine and herbal teas made from rosemary, sage and oregano on a daily basis. Icarians who observe the Greek Orthodox Church calendar must undergo regular fasts. Caloric restriction is known to slow the aging process in mammals.

Common characteristics of regions where people live better and longer

People in the Blue Zones, Okinawa, Sardinia, Nicoya, Icaria and Loma Linda, share characteristics in their lifestyles that contribute to their longevity. Dan Buettner in his book The Blue Zones lists 9 common characteristics:

• Moderate, regular physical activity throughout life.
• Caloric restriction.
• Semi-vegetarianism, with most of the food coming from plants.
• Moderate alcohol consumption (especially red wine).
• To give meaning to one’s life.
• Reducing stress.
• Commitment to spirituality or religion.
• Family is the center of life.
• Social commitment, integration in the community.

These blue zones have in common that they are sunny and airy areas. They are also relatively isolated, either geographically or according to religious practices (Loma Linda). The diets are different, but they have two aspects in common. The first is that they are based on plant-based foods, with meat, fish or cheese only in small amounts or during holidays, local, fresh, minimally processed foods. The second is that they eat vegetables. As for the flavors, the diets are very different. If the population of Icaria has a diet close to the Cretan diet (vegetables, fish, white meat), the population of the Sardinian mountain villages do not eat fish but meat, including cold cuts.

The study published by Michel Poulain and Gianni Pes identifies the importance of a healthy lifestyle, at high altitude, with physical activity, even over the age of 80, without stress, with close family and social ties. 

A very strong social bond

« Longevity (in these areas) is explained 10% by genes and 90% by lifestyle, » said Dan Buettner, in his book-investigation « Blue zones: Where do we live better and longer? « .

The social link is at the heart of the particular lifestyle of the « blue zones ».  The case of the Nicoya Peninsula in Costa Rica demonstrates this well. In certain homes in this region, it is not uncommon for three or four generations to live together. A study conducted by the German Max-Planck Institute has proven that regular babysitting of grandchildren improves cognitive function, mental and physical health, reduces the risk of developing Alzheimer’s disease and prevents stress. Passing on the knowledge and memories of grandparents to their offspring also helps them exercise their memory. Another example of the importance of social ties is the Seventh-day Adventist community in Loma Linda, California, the fifth largest blue zone in the U.S., dubbed the « longevity oasis”. There, believers live together and work daily for a common good, creating a strong sense of belonging. This sense of belonging goes beyond simply being kind to one another. Faith is a prominent factor. Together, it’s harder to give in to temptation, so a shared struggle creates beneficial social support that helps reduce mortality.

Meals are also an important source of social connection. According to dietician-nutritionist Alexandra Retion: « It is less and less important, but the happiest people are those who share their meals, who spend time with family or friends. It is very important to take the time to eat together and to share good moments. Conviviality is important. « France is rather a good student in this field because in 2010, UNESCO decided to classify the « gastronomic meal of the French » as intangible cultural heritage of humanity. A distinction that recognizes this social practice based on conviviality, the pleasure of taste, sharing, the association with wine, the link to the land, etc.

By way of conclusion

For a long time, humans have sought mythical places of longevity. Sometimes beliefs about longer life are simply due to unreliable records of births and deaths and an exaggeration of longevity. For example, even today, some people believe that the people of Hunza have the secret of living to 145 years.

The blue zones will not allow us to live forever. However, they do teach us that we can still make significant progress in healthy longevity, even without a breakthrough medical discovery. This can save a few years of healthy life, even compared to the longevity of the already most favored countries.

This month’s good news: Insects can also tell us about healthy longevity

We know that the maximum lifespan is genetically fixed. No mouse (Mus musculus) in the world lives more than 4 years, no human being more than 122 years, and no gastrotrich (small marine invertebrate) lives more than a few days. 

However, among social insects, maximum life spans vary considerably depending on the role of the individual. An article in Science details this situation. The most striking example is that of the queen termite, a gigantic « egg-laying machine », which lives up to 20 years, whereas the workers live only two years. The difference in lifespan also concerns the queens of bees and ants. 

The study of arthropods therefore holds out hope. Especially since some of these insects contradict the general principle that small animals have short life expectancy.

For more information:

• See in particular : heales.org, sens.org, longevityalliance.org and longecity.org.
• Source of the image

The law is already strict on rapamycin and metformin, requiring a prescription. In comparison, alcohol and tobacco do not require a prescription or medical supervision. Smoking has no health benefits and dramatically reduces life span, accelerating all diseases. While smoking causes cancer, rapamycin prevents it, including smoke-induced lung cancer. Is it then paradoxical that alcohol and tobacco are sold without prescription, while rapamycin and metformin are not. 

Blagosklonny M. V. The goal of geoscience is life extension. Oncotarget. 02 February 2021; 12: 131-144

Theme of the month: Fertility, longevity & menopause

While men are fertile every day, women’s fertility is cyclical. In fact, most girls are born with a certain stock of oocytes from birth, and even a little before. This stock varies between 300,000 and 500,000, of which an average of 400 will actually mature. From puberty onwards, an oocyte is released at each cycle and then eliminated by menstruation when there is no fertilization and over the years, this stock of oocytes decreases. 

And when they’re gone… they’re gone… It marks the end of a woman’s fertility cycle and the arrival of menopause!

Nature is such that, spontaneously, around the age of 50, a woman’s body undergoes a major hormonal change. The health consequences attributed to this change are multiple and variable, both in frequency and in severity. Symptoms include climacteric disorders (hot flashes, chills, feelings of discomfort and dizziness, etc.), mood and sexual disorders (decreased libido, pain during sexual intercourse, vaginitis, etc.), as well as an increased risk of cardiovascular disease and osteoporosis.

When the ovaries quit …

However, for some women, menopause strikes very early. Even before blowing out 40 candles, their lives are turned upside down. A report published on the American website Health explains the 5 reasons why some women are subject to early menopause. Among the factors influencing the age of menopause, there is the genetic factor. In 20% of the cases, a woman who went through menopause very early was not the only one in her family to suffer from this problem. Certain treatments such as chemotherapy and radiotherapy can also affect the genetic material of ovarian cells. But not only that, smoking and being overweight can also be responsible. Several studies state that on average, menopause occurs 2 years earlier in smokers. On the other hand, an overall improvement in diet, hygiene and quality of life in Western countries has put off the average age of menopause.

And among the animals?

Menopause seems to be unique to women… and to cetaceans. This early cessation of reproduction is rare in the animal world. On Earth, only women and four other animal species (the beluga, the narwhal, the killer whale and the pilot whale) experience menopause, a phenomenon among mammals that intrigues scientists. For example, female orcas can expect to live to over 90 years of age, but astonishingly they reach menopause between the ages of 30 and 40. 

But why should a female stop reproducing before the end of her life? This physiological cessation is often described as an evolutionary paradox, as it appears that females derive no benefit from ending their reproductive careers well before death. In a recent study published in Scientific Reports, conducted by researchers from the University of Exeter (UK) and the Center for Whale Research (USA), Dr. Samuel Ellis explains that « For menopause to make sense in evolutionary terms, a species needs both a reason to stop reproducing and a reason to live afterwards”.

The British researcher suggests the « grandmother effect » as an explanation. This hypothesis had been formulated by the anthropologist Kristen Hawkes and her colleagues to understand why menopause occurred during the evolution of humanity. Menopause would have been selected by natural evolution to allow females of very sociable species with a long life expectancy to devote themselves to their direct offspring and those of their children without running the risk of dying during a late pregnancy. After a few generations, a post-menopausal female will therefore have passed on her genes to more offspring than a female who has continued to give birth.

In tribes of hunter-gatherers, it has been found that the chances of survival of the young until the age of reproduction, is positively correlated to the presence of one or two of their grandmothers, certainly because they relieve the mothers in the burdens of child-rearing.

Inmost animals, as in our pets (dogs, cats, mares, cows…), we observe that over the years, the cycle becomes more irregular, that fertility decreases and health concerns can appear because of the drop in sexual hormones, but we cannot call this a real menopause.

Paradoxically, this phenomenon does not exist in any primate. Our closest cousins can become pregnant until the very end of their lives because their reproductive organs slow down with the rest of their bodies. Chimpanzees can remain reproductively viable for more of their lifespan than women. Although research published in 2011 on captive chimpanzees indicates that females go through menopause in their final years.

More surprisingly, in elephants we observe this « grandmother effect » which may explain the usefulness of menopause. However, the females can reproduce until the end of their lives. Scientists do not yet know why cetaceans have a menopause and elephants do not. More studies are needed to solve the mystery…

Birds do not experience menopause either. Some can remain fertile for a very long time. Wisdom, a female Laysan albatross defies nature. The oldest wild bird in the world had a chick at the age of 70! 

Pregnancy after 50? Is it possible to reverse menopause? 

Menopause can be considered either as a natural part of aging or as a pathology that needs to be treated.

It is often said that pregnancy after menopause is impossible. However in 2016, scientists at the Fertility Clinic in Athens managed to reverse the menopause process in a 45-year-old woman even though she had been menopausal for 5 years! 

The scientific team injected the ovaries of about 30 menopausal women with platelet-rich plasma (PRP). It is widely used to speed up the repair of damaged bones and muscles. The women who received the PRP treatment were all between 45 and 49 years old and had not had a period for several months. Six months after receiving a PRP injection, the 45-year-old woman noticed her period returning. The newly released eggs can be collected and fertilized in vitro. This offers a new window of hope for women suffering from early menopause.

In 2020, Dr. Konstantinos Pantos and his scientific teams obtained even more astonishing results: menopausal women gave birth after a PRP injection! Their fertility is said to have been restored thanks to the PRP treatment. Among the 30 menopausal volunteers, four became pregnant and three had children.

Cryopreservation to delay menopause by 20 years! 

This is at least what specialists in in vitro fertilization in Great Britain affirm. Their method has already been tested on nine women. The procedure consisted of taking ovarian tissue which is then frozen to be preserved. Later on as they enter menopause, the frozen tissue can be defrosted and transplanted back into the body to restore declining hormone levels. 

However, experts believe that it is possible to delay the onset of menopause by up to 20 years, but this depends on the age at which the tissue is removed and when it is put back in. For example, tissue taken from a 25-year-old woman could delay menopause by 20 years, while tissue taken from a 40-year-old could delay its onset by only five years.

Conversely, some beauty products bring forward the age of menopause…

According to Dr. Amber Cooper and her team (United States), exposure to chemical molecules, contained in particular in beauty products, can advance the age of menopause by 4 years. Between 1999 and 2008, they conducted blood and urine tests on 31,500 women to check for the presence of chemicals. The researchers found that women with high levels of chemicals in their bodies went through menopause 1.9 to 3.8 years earlier than women with lower levels.

The value  of rodents in the fundamental understanding of key elements in the reproductive and aging processes… 

We wrote earlier that only a few animals experience menopause. However, rats (and mice), at least in the laboratory, gradually cease to be fertile well before their maximum lifespan. Indeed, a rat can live more than three years, but its fertility decreases sharply after 10 months.

As we have seen, the effect of platelet-rich plasma (PRP) has had a positive effect in postmenopausal women in Greece.

In 2018, scientific teams wanted to evaluate the effect of PRP on ovarian structures and function in cyclophosphamide (Cy)-induced ovarian failure in female rats using a stereological method. The researchers concluded that it appears that PRP has a protective effect on ovarian failure in the infertile female rat model.

Rats and mice are imperfect but extremely useful models to better understand and combat the mechanisms of aging. However, to be certain of the effectiveness of a treatment, the maximum lifespan with or without treatment must be compared. This can take a long time since a rat can live more than 3 years. 

By examining the fertility of rats with anti-aging treatments, the information in the laboratory can be obtained much faster. An « ordinary » laboratory rat is 6 months old when experiments begin. After only 4 months of treatment, it will be possible to see if treated rats, compared to control rats, remain more fertile and therefore age less.

It should be noted that longevity experiments are done with a much more pleasant treatment of the animals than the life of sewer rats. This can be explained by the demanding protective legislation and because the goal is to make them live longer, good treatment favors it.

The (relatively) good news of the month:

 The fight against Covid through vaccination is making progress  

To speak of good news about this disease is very relative. There are nearly 3 million deaths recorded. New mutations are appearing more and more. The fine declarations concerning the vaccine, a common good of humanity, have been followed by little effect. Collaboration across financial, social and political barriers is difficult. Finally, populations are exhausted by restrictive measures.
But all is not bleak. By the first quarter of 2021, a big year after the pandemic broke out, more than 100 million people worldwide will have been vaccinated. About 10 vaccines are now being administered worldwide. The vaccines seem to be effective against the different variants of the disease.

As the elderly are the first victims, they are also very often the first to be vaccinated. Never in the history of mankind have we been so concerned about the weakest people in society and about research on this subject.  This is progress for all of humanity. Finally, the realization that Covid is just one of the many age-related diseases is gradually growing. And research to end Covid is sometimes extended to research against other age-related conditions.

For more information:

• See in particular: heales.org, sens.org, longevityalliance.org et longecity.org.
• Source of the image

…will we be able to live forever remains an unanswered question; turning a hundred years old into the new sixty – that is significantly extending human lifespan – has changed from a question of « if » to a matter of « when ». Peter Diamandis, entrepreneur, engineer, futurist. Page 179. The Future Is Faster Than You Think.

Theme of the month: Longevity, amortality, transhumanism, technoprogressism

It is one of humanity’s oldest dreams, health without any time limit. We all wish each other this in the New Year. Good health. We know more and more about why and how aging occurs. But we still cannot control senescence.

Not all those who wish to go beyond our biological limits, beyond 100 years of life, will define themselves as transhumanists. On the other hand, almost all transhumanists will describe themselves as longevitists.

What is longevitism?

It is the search for a much longer life, beyond what is possible today, thanks to advances in science and medicine.

Longevitism arouses both attraction and opposition. The opposition isoften motivated by the fear of false hopes, the fear of living longer but in poor health and the fear of therapies only for the rich. 

Longevitists want research for a healthy life, based on serious scientific evidence and are generally attentive to broad accessibility.

Their research may be moderate, aimed at and only a few more years of good health. It can be strong, aiming for a life of well over 120 years.

So the goal of these therapies is to strongly reduce or even eliminate the mechanisms of senescence. The most optimistic will aim at what is called « biological immortality« , the absence of any aging mechanism. The term « amortality » is also used.

What is transhumanism?

Let’s take Wikipedia’s definition: it is a philosophical movement that advocates for the transformation of the human condition by developing and making widely available sophisticated technologies able to greatly modify or enhance human intellect and physiology.

The word transhumanism sometimes frightens people because it evokes the appealof dangerous, dehumanizing technologies. The vast majority of transhumanists are aware of the dangers linked to technical progress. They actively wish for technologies to reduce risks, especially the so-called « existential » ones, to increase resilience and thus the quality and duration of life.

The improvements that transhumanists aim for can be physical: higher, stronger, further, more adapted to the environment. It can be related to the sense organs (better sight, smell, new sensory capacities…). The improvements aimed at can also be related to intellectual capacities. The goal is then to allow more intelligence, more capacity for empathy, compassion, happiness …

But the improvement most often envisaged by transhumanists is that of the improvement of life expectancy, thus the objective of longevitists. This is the necessary, but not sufficient condition for all other increases, for all human rights. Without sustainable life, there are no rights, no possibilities.

What is technoprogressism?

Technoprogressism is a transhumanism for which the idea of linking technological and social progress is central. When we look at the history of humanity, we see that technological progress has largely contributed to social progress and vice versa. But this is not automatic. Technoprogressists will insist on accessibility to technological progress for all those who want it. This applies in particular, of course, to health and longevity therapies.

One of the main founders of transhumanism, Briton David Pearce, summarized transhumanism by 3 S’s: Superlongevity, Superintelligence and Super well-being. Technoprogressists sometimes add « Super democracy » or Supersocial.

“Biological » longevity and « computer » longevity.

For most contemporary longevitists, the ultimate goal is a much longer life with an « ordinary » body, not so different from the contemporary body.

This concept of « ordinary body » must be put into perspective. We already accept today many things that would have appeared totally unnatural even to the most erudite two centuries ago. We transfuse blood, we almost all have foreign bodies in our mouths. At the end of our lives, most of us will have gone through a physiological state that does not exist outside of medicine, somewhere between sleep and death. We call it general anesthesia. Millions of humans have been conceived in a test tube. Millions of us also have pacemakers, cochlear implants… In fact, what yesterday was unimaginable transgression is today medicine. And today’s transhumanism could be tomorrow’s medicine.

But for some more radical transhumanists and longevitists, we could go far beyond our biological composition. Man-machine « fusion » could develop, concerning an increasingly large part of the body, creating a cyborg. Further still, one day, human consciousness could become independent of the body, be transferred onto a computer medium. This vision was discussed in a letter in 2012. It remains today totally hypothetical within a reasonable timeframe. For most longevitists, and probably also for most transhumanists, this could only become possible where computers reproduce biological processes as well as or even better than the processes themselves.  Where the virtual copy would be better than the original. Like a beautiful film can be more beautiful than reality. Like a game can be more enjoyable than the situation that gave birth to it.

This requires nanotechnology and computer efficiency far beyond current capabilities. Above all, it implies being able to understand and replicate the neural mechanisms of what is often defined as « the most complex object in the known Universe« .

Longevity, transhumanism, artificial intelligence

The IT of the near future is above all the development of an increasingly strong artificial intelligence, developed to facilitate human interests. Longevitists, transhumanists or not, hope, and try, to implement computing processes allowing better and faster research. An acceleration of discoveries for health, longevity and resilience also requires massive data that is easilyaccessible and well organized.

Using research capabilities primarily for these purposes, rather than for competitive, military or consumer purposes, is likely to reduce the risks associated with artificial intelligence. Making the best « brains », both human and computational, work together for a much longer healthy life will reduce the risks of developing intelligence that is far removed from human beings.

This is important because the risks of an artificial intelligence « turning radically wrong » are considered high by many. Among those who are concerned, there are many transhumanists, including Nick Bostrom, author of a renowned book on the subject.

More human, tomorrow

Longevitists generally focus first on medical progress and everything that contributes to it. Transhumanists, especially technoprogressists, also seek to analyze why this progress is important. They will explain that a much longer life will make it possible to have

– a more peaceful life, with less violence and more caution;

– to love each other more and to stress us less, since we will have more time;

– to be more careful about the biosphere because we will know that we are here for the long term. A sustainable body is not possible without a sustainable planet.

– Less overpopulation, and more attention to children. For it is where life is longest that children are the rarest and that we have the most time to devote to them.

For these and other reasons, the age-old quest for the Fountain of Youth is today a more desirable and reasonable goal than ever. Today, we still have to accept death from old age because we have no choice. Tomorrow we may choose.

This month’s good news: Conference and workshops on February 11, 2021 on animal and human testing for longevity. Support from Heales for two studies testing the lifespan of rats treated with young plasma.

The February 11th conference on the topic « Clarifying whether and to what extent current anti-aging approaches work in mice or people » was a great success with more than 100 participants.

Present were specialists on the subject such as Irina Conboy, Nir Barzilaï, Greg Fahy and Liz Parrish to name but a few. If you wish to discover them all, the conference split up by speaker remains accessible.

A synthesis of the proposals made during the workshops has been produced.

Since the beginning of 2021, the Heales association has been supporting two studies, carried out by Rodolfo Goya in Argentina and Harold Katcher in India, each following the maximum lifespan of rats treated with blood products, in order to verify the beneficial effect on longevity of this type of treatment.

If significant longevity results are not achieved, this will « close a door ». If important longevity results are established, this will be extremely important news. The conviction of most researchers and the association is that the first hypothesis is the right one. But we would love to be proved wrong!

Find out more:

• See in particular : heales.org, sens.org, longevityalliance.org and longecity.org.
• Source of the image.